Corticosteroid 11 Beta Dehydrogenase Isozyme 1 (11 Beta Hydroxysteroid Dehydrogenase 1 or Short Chain Dehydrogenase/Reductase Family 26C Member 1 or HSD11B1 or EC 1.1.1.146) - 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. This enzyme plays an important role in obesity and insulin resistance. Covers products from therapy areas: Metabolic Disorders, Central Nervous System, Ophthalmology, Cardiovascular, Immunology and Musculoskeletal Disorders which include indications Type 2 Diabetes, Alzheimers Disease, Dementia Associated With Alzheimers Disease, Obesity, Ocular Hypertension, Open-Angle Glaucoma, Cushings Syndrome, Diabetic Complications, Inflammation, Intracranial Hypertension, Metabolic Syndrome, Muscle Atrophy, Myocard...
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